Adding a certain compound to certain chemical reactions, such as: 75853-18-8, 2,3-Difluorobenzyl alcohol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2,3-Difluorobenzyl alcohol, blongs to alcohols-buliding-blocks compound. Recommanded Product: 2,3-Difluorobenzyl alcohol
Solid NaH (17 mg, 0.7 mmol, 7 eq. ) was added to a stirred solution of 2, 3-difluorobenzyl alcohol (0.10 g, 0.7 mmol, 7 eq. ) in dry benzene (5 mL) at 0 °C The solution was allowed to reach RT over 15 min. The product from step (a) (45 mg, 0.1 mmol, 1 eq. ) was added as a solid and the mixture was heated to reflux for 1 h. After cooling to RT, the reaction was quenched by addition of saturated aqueous NH4C1 (1 mL). The mixture was partitioned between EtOAc (10 ML) and water (10 mL). The organic phase was separated, dried over NA2S04 and evaporated. The oily residue was purified by preparative HPLC to give the title compound as an off-white solid (4.5 mg, 11 percent yield). IH NMR (CDCl3) 8 9.80-9. 20 (br s, 1H), 7.80 (s, 1H), 7.69-7. 29 (m, 3H), 6.50 (m, 1H), 5.49 (s, 2H), 4.41 (m, 1H), 3.78 (dd, 1H), 3.64 (dd, 1H), 1. 68-1. 48 (m, 3H), 0.95 (d, 3H), 0.91 (d, 3H); MS (EST) 7N/Z 406 [M+H].
The synthetic route of 75853-18-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; WO2005/33115; (2005); A1;,
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