Related Products of 162358-05-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 162358-05-6, name is 2-(4-Octylphenyl)ethanol. A new synthetic method of this compound is introduced below.
Example 6 Preparation of Compound of Formula VIIIn a round bottom flask, 600 ml of methylene chloride was charged and 100 gm of compound of Formula V, obtained as in Example 4, and 5.0 gm of DMAP and 110 gm of triethyl amine was added. The reaction mass was stirred for about 10 minutes and cooled at about 0-5 C. 75 gm of methane sulphonyl chloride was added at about 0-5 C. and the temperature of reaction mass was raised to about 25-30 C. The reaction mass was stirred at about 25-30 C. for about 1 hour and water (500 ml) was added to the reaction mass. The pH was adjusted to about 2-4 by using aq. HCl and the reaction mass was stirred for about 20 min. The organic layer was separated and washed with 7% bicarbonate solution followed by washing with brine. The organic layer was treated with charcoal and distilled out under vacuum and degassed to get 110 gm of compound of Formula VI.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,162358-05-6, 2-(4-Octylphenyl)ethanol, and friends who are interested can also refer to it.
Reference:
Patent; Glenmark Generics Limited; Gharpure, Milind; Narawade, Krishna; Chand, Prem; Bhirud, Shekhar; US2015/18578; (2015); A1;,
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