With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2867-59-6, name is 3-Aminobutan-1-ol, molecular formula is C4H11NO, molecular weight is 89.14, as common compound, the synthetic route is as follows.Application In Synthesis of 3-Aminobutan-1-ol
in a microwave-tube, ethyl 2-[benzyloxycarbonyl(2-oxoethyi)amino]acetate (330 mg, 1 .18 mmol) was diluted in DCM (8 ml), then (+/-)-3-aminobutan-1-ol (1 16 mg, 1.24 mmol) and acetic acid (39 muIota, 673 prnol) were added to give a colorless solution. The reaction mixture was submitted to microwave heating for 1.5 h at 140 C. The reaction mixture was concentrated in vacuo and the residue was purified by flash chromatography (silica gel, 0% to 50% EtOAc in heptane) to give the title compound (183 mg, 51 %) as a colorless oil. The relative stereochemistry of the product was unambiguously assigned by NOESY NMR experiments. (1085) MS (ESI, m/z): 305.2 [(M+H)+].
At the same time, in my other blogs, there are other synthetic methods of this type of compound,2867-59-6, 3-Aminobutan-1-ol, and friends who are interested can also refer to it.
Reference:
Patent; SAVIRA PHARMACEUTICALS GMBH; EUROPEAN MOLECULAR BIOLOGY LABORATORY; LERNER, Christian; KREIS, Lukas; HILPERT, Hans; (268 pag.)WO2017/158151; (2017); A1;,
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