Adding a certain compound to certain chemical reactions, such as: 597-31-9, 3-Hydroxy-2,2-dimethylpropanal, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 3-Hydroxy-2,2-dimethylpropanal, blongs to alcohols-buliding-blocks compound. Recommanded Product: 3-Hydroxy-2,2-dimethylpropanal
EXAMPLE 1Preparation of an Aqueous Polymethylol Mixture by the Hydrogenation ProcessStage a) Aldol Reaction:Approx. 750 g/h of isobutyraldehyde (approx. >99.5 GC area % of IBA) were reacted with approx. 700 g/h of formaldehyde (approx. 49% formaldehyde, 1.5% of methanol, remainder water) and 80 g/h of trimethylamine solution (50% TMA in water) in a two-stage stirred tank cascade.Stage b) Distillative Separation of the Reaction Mixture from Stage a):Subsequently, the solution was freed of low boilers by distillation in a column. The column was equipped with 1.5 m of fabric packing (specific surface area 500 m2/m3) in the rectifying section and 4 m of sheet metal packing (250 m2/m3). The aldolization discharge was fed in above the sheet metal packing. At the top of the column, a condenser with cooling water (approx. 10 C.) and a downstream phase separator was used. At the top, the distillate was fed to the condenser in gaseous form. Approx. 255 g/h of liquid condensate were obtained. In the phase separator connected downstream, an aqueous phase of 95 g/h was removed and fed completely to the column. In addition, 135 g/h were fed from the phase separator to the first stirred tank. In order to maintain the regulation temperature in the column at 85 C., 25 g/h of organic phase were additionally fed to the column. In the cold trap connected downstream of the condenser, approx. 1 g/h of liquid was obtained (approx. 80% IBA, approx. 20% TMA), which was likewise recycled.The IBA removal was conducted at a top pressure of approx. 1 bar absolute. The evaporator used was a falling film evaporator. A bottom temperature in the bottom of the column of 104 C. was established. The reflux rate (i.e. cooling water rate of the partial condenser) to the column was regulated by means of the temperature in the middle of the fabric packing; a temperature of 85 C. was established.By means of a pump, approx. 100 kg/h of liquid were drawn off from the bottom of the column. This was fed to the falling film evaporator (consisting of an oil-heated stainless steel tube, length 2.5 m, internal diameter approx. 21 mm, wall thickness approx. 2 mm). Approx. 1.5 kg/h of product with a concentration of approx. 0.3% isobutyraldehyde were drawn off from the bottom of the falling film evaporator. The vapors and excess liquid were fed to the bottom of the column. The bottom product discharged comprised approx. 70% by weight of HPA, approx. 1.5% by weight of HPN, 0.3% by weight of IBA, remainder water.Stage c) Hydrogenation of the Bottom Discharge from Stage b):The resulting bottom product was subsequently subjected to a hydrogenation by means of a fixed bed.The catalyst was activated as follows:150 ml of a Cu/Al2O3 catalyst as described in EP 44444 and PF57216 were activated in a tubular reactor at 190 C. by passing over a mixture of 5% by volume of hydrogen and 95% by volume of nitrogen (total volume 50 l (STP)/h) at ambient pressure for 24 hours.The hydrogenation was performed as follows:The starting solution used was the mixture described above as hydrogenation feed. Approx. 10% by weight based on the hydrogenation feed of a 15% aqueous solution of trimethylamine was added to the mixture. The feed thus obtained was conducted in trickle mode at H2 pressure 40 bar through the reactor heated to 120 C. The space velocity was 0.4 kg of HPA/(Icat*h). A portion of the hydrogenation discharge was added again to the feed (circulation mode). The ratio of circulation to feed was 10:1. The pH of samples of the reactor discharge at room temperature was measured at 8.9.The composition of the aqueous polymethylol mixture from stage c) was:NPG: 69% by weight Methanol: 3.5% by weight TMA: 2% by weight. organic secondary compounds (HPA, isobutanol): <2% by weight TMA formate: 1% by weight Water: 23% by weight
At the same time, in my other blogs, there are other synthetic methods of this type of compound,597-31-9, 3-Hydroxy-2,2-dimethylpropanal, and friends who are interested can also refer to it.
Reference:
Patent; BASF-SE; US2012/4472; (2012); A1;,
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