Reference of 534-03-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 534-03-2, name is 2-Aminopropane-1,3-diol. A new synthetic method of this compound is introduced below.
45.6 g of 2-amino-1,3-dihydroxypropane was mixed with 113 mL of formic acid solution,Then add 90 mL of 37% formaldehyde solution.The mixture was stirred at room temperature for 2h,The reaction was then warmed to 80 C,And kept at this temperature overnight.When the temperature reaches 80 , there will be a lot of gas discharge. After the reaction was completed, it was cooled to room temperature. 60 mL of 37% strength hydrochloric acid was added and stirred for 1 h.Solid sodium hydroxide was added to adjust the pH of the solution to 12, the mixture was distilled under reduced pressure,Add a lot of methanol.At this point the white precipitate generated in the system filter, the filtrate was distilled off under reduced pressure,The concentrated initial product was dissolved in trichloromethane and dried over anhydrous magnesium sulfate.In the conditions of 100 -102 / 100Kpa by distillation,40.9 g was obtained2-N, N-dimethyl-1,3-dihydroxypropane,The yield was 68.65%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,534-03-2, 2-Aminopropane-1,3-diol, and friends who are interested can also refer to it.
Reference:
Patent; University of Science and Technology Beijing; Gong Aijun; Yang Jing; Qiu Lina; Xie Yanping; Zhao Yunbo; (9 pag.)CN105198773; (2017); B;,
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