Electric Literature of 2566-44-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2566-44-1, name is 2-Cyclopropylethanol. A new synthetic method of this compound is introduced below.
General procedure: Example 5-01 (Typical Procedure 10) [0342] A mixture of (R)-3-(2-bromo-pyridin-4-yloxy)-1-(7-fluoro-3-oxo-indan-5-yl)-pyrrolidin-2-one (80 mg), 2-cyclopropyl-ethanol (85 mg), cesium carbonate (129 mg) and toluene (1.6 mL) under argon was added Pd(OAc)2 (443 mug) and 5-(di-tert-butylphosphino)-1?,3?,5?-triphenyl-1?H-[1,4?]bipyrazole (2.0 mg). The mixture was heated to 90 C. for 2 hours by microwave irradiation. After cooling to room temperature the mixture was filtered and concentrated. The residue was purified by preparative HPLC to provide Example 5-01.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2566-44-1, its application will become more common.
Reference:
Patent; SANOFI; SCHWINK, Lothar; BOSSART, Martin; GLOMBIK, Heiner; GOSSEL, Matthias; KADEREIT, Dieter; KLABUNDE, Thomas; MAIER, Thomas; STENGELIN, Siegfried; US2014/99333; (2014); A1;,
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