In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 87327-65-9, name is 1-(2,6-Difluorophenyl)ethanol, the common compound, a new synthetic route is introduced below. Safety of 1-(2,6-Difluorophenyl)ethanol
Example 105 2-[1-(2,6-Difluoro-Phenyl)-Ethoxy]-6-(1-Piperazinyl)Pyrazine, Maleate. The title compound was prepared according to the procedure of example 50, step 2, starting from 2-chloro-6-[1-(2,6-difluoro-phenyl)-ethoxy]pyrazine (3.20 g, 11.8 mmol; obtained according to the procedure of example 50, step 1, starting from 2,6-difluoro-alpha-methylbenzyl alcohol), piperazine (3.05 g, 35.4 mmol) and K2CO3 (1.63 g, 11.8 mmol) with the exception that the final filtration through alumina was omitted. The yield of the free base of the title compound was 2.95 g (78%) which was obtained as a colorless oil. The free base was converted into its maleate salt. Purity 100% (HPLC). MS m/z 320 (M)+. HRMS m/z calcd for C16H18F2N4O(M)+320.1449, found 320.1447.
The synthetic route of 87327-65-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Nilsson, Bjorn M.; US2002/147200; (2002); A1;,
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