Electric Literature of 35106-82-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.35106-82-2, name is (2-Vinylphenyl)methanol, molecular formula is C9H10O, molecular weight is 134.1751, as common compound, the synthetic route is as follows.
Step 1: 2-vinylbenzyl acetate To a solution of (2-vinylphenyl)methanol (3.0 g, 22.4 mmol) and triethylamine (4.5 g, 44.7 mmol) in DCM (20 mL) was added acetic anhydride (Ac2O) (4.6 g, 44.7 mmol) and catalytic amount of 4-dimethylaminopyridine (DMAP) (50 mg). The resulted mixture was stirred at room temperature for overnight, and then diluted with DCM (30 mL). The organic layer was washed with H2O and brine successively, dried over sodium sulfate, filtered and concentrated. The residue was purified by column chromatography on silica gel to afford 2-vinylbenzyl acetate (3.9 g, yield: 96percent) as light yellow oil.
Statistics shows that 35106-82-2 is playing an increasingly important role. we look forward to future research findings about (2-Vinylphenyl)methanol.
Reference:
Patent; SHANGHAI DE NOVO PHARMATECH CO. LTD.; GAO, Daxin; YANG, Heping; WANG, Pei; (84 pag.)US2017/37038; (2017); A1;,
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