Synthetic Route of 15852-73-0, Adding some certain compound to certain chemical reactions, such as: 15852-73-0, name is (3-Bromophenyl)methanol,molecular formula is C7H7BrO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 15852-73-0.
(d) 3-r3-Hvdroxymethylphenyl)-5-/j’o-butyl-N-fert-butyltm’ophene-2-sulfonamide; A mixture of roe-bromobenzyl alcohol (1.05 g, 5.80 mmol), 5-iso-butyl-2-(/V-tert- butylaminosulfonyl)thiophene-3-boronic acid (2.41 g, 7.55 mmol; see step (c)), Pd(PPh3)4 (270 mg, 0.235 mmol), NaOH (19.1 mL, 1.5 M aq5 28.6 mmol), EtOH (5.0 mL) and toluene (30 mL) was stirred under N2 at 9O0C for about 4 h. After cooling, water (10 mL) was added to the reaction mixture and this was then extracted with ethyl acetate. The combined organic phase was dried and concentrated in vacuo. The crude product was purified on column EPO
According to the analysis of related databases, 15852-73-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; VICORE PHARMA AB; WO2006/109056; (2006); A1;,
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