Adding a certain compound to certain chemical reactions, such as: 101597-25-5, 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, blongs to alcohols-buliding-blocks compound. Quality Control of 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol
Example 1; 1.15 g (2.33 mmol) of a naphthol compound represented by the following formula (15) and 0.92 g (3.43 mmol) of a propargyl alcohol compound represented by the following formula (16) were dissolved in 50 ml of toluene, 0.022 g of p-toluenesulfonic acid was further added, and the obtained mixture was refluxed for 1 hour. After the reaction, the solvent was removed, the obtained product was purified by column chromatography, and crystallization was carried out with methanol (5 ml) to obtain 1.21 g of a white powder (yield rate of 70 %). The elemental analysis values of this product were 75.66 % of C, 6.44 % of H and 3.71 % of N which were almost equal to the calculated values of C47H47F3N2O3 (C: 75.78 %, H: 6.36 %, N: 3.76 %). When the proton nuclear magnetic resonance spectrum of the product was measured, it showed 31H peaks based on an alkyl group and an alkoxy group at delta of around 0.5 to 4.5 ppm and a 16H peak based on an aromatic proton at delta of around 5.0 to 9.0 ppm. Further, when the 13C-nuclear magnetic resonance spectrum was measured, it showed a peak based on the carbon of an aromatic ring at delta of around 110 to 160 ppm and peaks based on the carbons of an alkyl group and an alkoxy group at delta of around 10 to 80 ppm. It was confirmed from the above results that the isolated product was a compound represented by the following formula (17).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,101597-25-5, 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, and friends who are interested can also refer to it.
Reference:
Patent; Tokuyama Corporation; EP2457915; (2012); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts