Synthetic Route of 19819-98-8 , The common heterocyclic compound, 19819-98-8, name is 2-(o-Tolyl)ethanol, molecular formula is C9H12O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
EXAMPLE 5 2-Methylphenethyl sulfamate A mixture of 2.65 g (0.019 mole) of 2-methylphenethyl alcohol in 10 ml DMF was added dropwise to a suspension of sodium hydride (1.1 g, 60% in oil; 0.08 mole) in 35 ml DMF at 0-5 C. The suspension was stirred for 20 min under argon after which sulfamoyl chloride (2.86 g, 0.02 mole) was added portion wise at 0-5 C. After stirring for 20 min the resultant suspension was poured into ice and extracted twice with Et2 O. The combined organic phases were washed with saturated brine, dried over potassium carbonate and concentrated in vacuo to a syrup which was purified by preparative HPLC with hexane/EtOAc (1:1, v/v) as the eluant to give 1.76 g (43%) of the title compound as a solid, mp 50-52 C. Elemental Analysis: Calculated for C9 H13 NO3 S: C, 50.22; H, 6.09; N, 6.51. Found: C, 50.40; H, 6.14; N, 6.43.
The synthetic route of 19819-98-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; McNeilab, Inc.; US4792569; (1988); A;,
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