Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3068-00-6, name is 1,2,4-Butanetriol. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 1,2,4-Butanetriol
General procedure: To a stirring solution of benzophenone (1 eq.) in anhydrous toluene, at room temperature and under nitrogen atmosphere, 1,2,4-butantriol (2 eq.) and pTSA (cat.) were added. The mixture was refluxed for 24?h, using Dean-Stark trap to remove the forming water. The mixture was then cooled at room temperature, and diluted with Et2O. The organic phase was washed with NaHCO3 saturated solution, brine, dried over anhydrous Na2SO4 and concentrated. The crude was purified by column chromatography (cyclohexane:EtOAc 85:15) to give alcohols 40 and 42.4.1.5.1 2-(2,2-Diphenyl-1,3-dioxolan-4-yl)ethan-1-ol (40) Colorless liquid (65% yield). 1H NMR (200MHz, DMSO-d6) delta 1.56-1.90 (m, 2H), 3.39-3.75 (m, 2H), 3.97-4.28 (m, 2H), 4.48 (t, J=5.1Hz, 1H), 7.16-7.53 (m, 10H). MS (ESI): m/z [M + H]+: 270.1.
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Reference:
Article; Franchini, Silvia; Sorbi, Claudia; Linciano, Pasquale; Carnevale, Gianluca; Tait, Annalisa; Ronsisvalle, Simone; Buccioni, Michela; Del Bello, Fabio; Cilia, Antonio; Pirona, Lorenza; Denora, Nunzio; Iacobazzi, Rosa Maria; Brasili, Livio; European Journal of Medicinal Chemistry; vol. 176; (2019); p. 310 – 325;,
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