Electric Literature of 558-42-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 558-42-9, name is 1-Chloro-2-methyl-2-propanol. This compound has unique chemical properties. The synthetic route is as follows.
To the mixture of 6-(3-Bromo-5-chloro-4-hydroxyphenyl)-5-methyl-4,5-dihydro-2H-pyridazin-3-one (Reference example 87, 300 mg) was dissolved in ethanol-water (4 : 1, 10 mL) were added 1-chloro-2-methyl-2-propanol (0.388 mL) and potassium carbonate (522 mg). The reaction mixture was refluxed for 8 hours. To the reaction mixture was added water, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and brine, dried over anhydrous sodium sulfate, and filtrated, and the solvent was removed. The obtained crude product was purified by silica gel column chromatography (heptane : ethyl acetate = 67 : 33 to 33 : 67). The obtained solid was recrystallized from 2-propanol to afford the title compound as a white powder (107 mg).Melting point : 176.6-178.2°C
According to the analysis of related databases, 558-42-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; OTSUKA PHARMACEUTICAL CO., LTD.; KATOH, Takahiro; IIDA, Masatoshi; TERAUCHI, Yuki; YAMAGUCHI, Kazuya; HIROSE, Toshiyuki; YOKOYAMA, Fumiharu; NISHIMORI, Hikaru; OBUCHI, Yutaka; NABESHIMA, Hiroshi; TAKAKI, Emiri; (250 pag.)WO2017/150654; (2017); A1;,
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