Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 24131-31-5, name is (3,5-Bis(benzyloxy)phenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. category: alcohols-buliding-blocks
Phosphorus tribromide was added to the CH2Cl2 solution (10 mL) of [3,5-bis(benzyloxy)phenyl]methanol (11, 0.008 mol) at 0 C for 2 h. Ice water was added to reaction solution, and extracted with diethyl ether. The crude product was evaporated and purified by silica-gel chromatography using petroleum/ethyl acetate 15:1 as an eluent to give bromide 12 (0.0028 mol, 35%). 1H-NMR (DMSO-d6, 300 MHz) delta: 7.11-7.43 (10H), 6.65 (2H, d, J = 2.1 Hz), 6.55 (1H, s), 5.03 (4H, br s), 4.35 (2H, s). HPLC analysis 96.9% (MeOH: H2O = 85: 15 (V/V), tR = 8.67 min).
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Reference:
Article; Wan, Xiang; Wang, Xiao-Bing; Yang, Ming-Hua; Wang, Jun-Song; Kong, Ling-Yi; Bioorganic and Medicinal Chemistry; vol. 19; 17; (2011); p. 5085 – 5092;,
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