Synthetic Route of 722-92-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 722-92-9, name is 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol. This compound has unique chemical properties. The synthetic route is as follows.
General procedure: The compound 1(4-(chloromethyl)benzoyl chloride, 12 mmol) was added dropwise to a mixture of 2a?n (10 mmol) and triethylamine (12 mmol) in dichloromethane (20 mL) at room temperature with stirring. Then the reaction mixture was refluxed for 4?6 h. After cooling to room temperature, the mixture was slowly poured to ice water (50 mL). The solution was extracted with dichloromethane (3×60 mL) and the organic phase was dried over with sodium sulfate anhydrous. After removal of the dichloromethane, the solid residue was purified by recrystallization with petroleum ether?ethyl acetate to give compounds 3a?n.
According to the analysis of related databases, 722-92-9, the application of this compound in the production field has become more and more popular.
Reference:
Article; Shi, Yao-Jie; Song, Xue-Jiao; Li, Xiao; Ye, Ting-Hong; Xiong, Ying; Yu, Luo-Ting; Chemical and Pharmaceutical Bulletin; vol. 61; 11; (2013); p. 1099 – 1104;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts