Analyzing the synthesis route of 19819-98-8

With the rapid development of chemical substances, we look forward to future research findings about 19819-98-8.

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 19819-98-8, name is 2-(o-Tolyl)ethanol, molecular formula is C9H12O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of 2-(o-Tolyl)ethanol

General procedure: To a 1 dram vial equipped with a stir bar was added the alcohol (0.080 mmol), isopropyl (S)-2-(tert-butoxy)-2-(4?-(4,4-dimethylpiperidin- 1 -yl)-5-hydroxy-6?-methyl- [2,3?-bipyridinj-5?-yl)acetate (25 mg, 0.053 mmol), and triphenylphosphine (20.9 mg, 0.080 mmol) as a solution in THF (0.25 mL). To the solution was added DIAD (0.016 mL, 0.080 mmol) as a solution in THF (0.25 mL). The solution was stirred at r.t. for 30mm to 18 h. The reaction solution was concentrated under a N2 stream. The residue wasdissolved in EtOH (1.0 mL). To the solution was added aq. NaOH (5.0 M, 0.110 mL,0.532 mmol). The vial was capped, then placed in a 85 C heating block with stirring for4 h to 18 h. The mixture was cooled to r.t., then was filtered through a 0.4 micron syringefilter and the filtrate was directly subjected to HPLC purification to afford the purifiedproduct.

With the rapid development of chemical substances, we look forward to future research findings about 19819-98-8.

Reference:
Patent; VIIV HEALTHCARE UK (NO.5) LIMITED; BELEMA, Makonen; BOWSHER, Michael S.; DESKUS, Jeffrey A; EASTMAN, Kyle J.; GILLIS, Eric P; FRENNESSON, David B; IWUAGWU, Christiana; KADOW, John F.; NAIDU, B. Narasimhulu; PARCELLA, Kyle E.; PEESE, Kevin M; SAULNIER, Mark G; SIVAPRAKASAM, Prasanna; (463 pag.)WO2018/127800; (2018); A1;,
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