Application of 5182-44-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5182-44-5, name is 2-(3-Chlorophenyl)ethanol, molecular formula is C8H9ClO, molecular weight is 156.6095, as common compound, the synthetic route is as follows.
In a flame-dried 250 mL round-bottom flask equipped with an argon line, the appropriate alcohol (21a-26a) (1 eq. ) was placed and was dissolved in ether/acetonitrile (3: 1). To this solution, triphenylphosphine (3 eq. ), imidazole (3 eq. ) and iodine (3 eq.) were added in this order. The reaction mixture was kept at room temperature for 1 hours and monitored by TLC. The reaction mixture was filtered and washed with ether. The organic layers were then washed with brine, dried over MgS04, filtered and concentrated in vacuo. The residue was purified via flash chromatography on silica gel eluting with 1% ethyl acetate/hexanes to give 21b-26b in 58-88% yield. m-Chlorophenethyl iodine (21b) H NMR (CDC13) : 8 7.21-7. 19 (q, 3H), 7.12 (t, 1H), 3.52 (t, 2H), 3.28 (t, 2H).’3CNMR (CDC13) : 8 140.90, 134.14, 129.69, 129.06, 127.02, 126.45, 38.69, 11,27. IR (liquid film) 2948,2879, 1598,1574, 1429 FT-ICRMS : m/z 267. 52 (M. +H).
The chemical industry reduces the impact on the environment during synthesis 5182-44-5, I believe this compound will play a more active role in future production and life.
Reference:
Patent; UNIVERSITY OF MISSISSIPI; WO2003/95444; (2003); A1;,
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