Synthetic Route of 5259-98-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5259-98-3, name is 5-Chloropentan-1-ol, molecular formula is C5H11ClO, molecular weight is 122.59, as common compound, the synthetic route is as follows.
General procedure: The thiophenylmannoside 1 (440mg, 1.00mmol, 1.0equiv) and the corresponding alcohol (1.05equiv) in CH2Cl2 (5mL) were stirred at 25 °C in the presence of 4 A MS (500mg) for 30 min. After cooling to ?2°C with an ice/NaCl bath N-iodosuccinimide (270mg, 1.2mmol, 1.2equiv) and trifluoromethanesulfonic acid (30.0mg, 17.7mL, 200mmol, 0.2equiv) were slowly added and stirring continued at this temperature for 1h. The reaction mixture was allowed to warm to 25 °C and then acetic anhydride (0.2-0.3mL, 2.0-3.0equiv) added. Work-up was analogous to GP1 and column chromatography was performed with a gradient 3:1?1:1 petrol/EtOAc to yield the mono, di and trisaccharides as colourless materials.
The chemical industry reduces the impact on the environment during synthesis 5259-98-3, I believe this compound will play a more active role in future production and life.
Reference:
Article; Schuster, Heiko J.; Vijayakrishnan, Balakumar; Davis, Benjamin G.; Carbohydrate Research; vol. 403; (2015); p. 135 – 141;,
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