Some scientific research about (2-(Trifluoromethyl)phenyl)methanol

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 346-06-5, (2-(Trifluoromethyl)phenyl)methanol, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 346-06-5, Adding some certain compound to certain chemical reactions, such as: 346-06-5, name is (2-(Trifluoromethyl)phenyl)methanol,molecular formula is C8H7F3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 346-06-5.

EXAMPLE 1052-(trifluoromethyl)benzyl 7-bromo-3-oxo-2,3-dihydrospiro[indene-l ,4′-piperidine]-r- carboxylate To o-(trifluoromethyl)benzyl alcohol (35 mg, 0.20 mmol) in CH2Cl2 (4 mL) was added was a solution of carbonyl diimidazole (29 mg, 0.18 mmol) in CH2Cl2 (4 mL). The mixture was stirred at rt for 2 h. A 1-mL aliquot of the resulting solution (0.05 mmol) was added to a solution 7-bromospiro[indene-l,4′-piperidin]-3(2H)-one (14.5 mg, 0.05 mmol) in CH2Cl2 ( ImL). The mixture was stirred at rt for 16 h, concentrated, redissolved in MeCN (1 mL) and heated at 60 °C for 2 h. Prep HPLC afforded the title compound. LC-MS Method 1 tR = 2.06, min, m/z = 484, 482.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 346-06-5, (2-(Trifluoromethyl)phenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; VITAE PHARMACEUTICALS, INC.; WO2009/108332; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts