With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.111-90-0, name is Diethylene Glycol Monoethyl Ether, molecular formula is C6H14O3, molecular weight is 134.1736, as common compound, the synthetic route is as follows.category: alcohols-buliding-blocks
General procedure: TMSOTf (336 mg, 1.51 mmol) is added to a solution of the alcohol (0.755 mmol) in the respective nitrile (3 mL) and the mixture is stirred at rt for 65 h. H2O (25 mL) and brine (25 mL) are added, and the mixture is extracted with EtOAc (3 × 30 mL). The combined organic layers are dried (Na2SO4) and concentrated, and excess nitrile is distilled off at reduced pressure (90 C, 0.1 mbar). The crude product is purified by flash column chromatography (silica gel).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,111-90-0, Diethylene Glycol Monoethyl Ether, and friends who are interested can also refer to it.
Reference:
Article; Pfaff, Dominik; Nemecek, Gregor; Podlech, Joachim; Beilstein Journal of Organic Chemistry; vol. 9; (2013); p. 1572 – 1577;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts