Adding a certain compound to certain chemical reactions, such as: 52273-77-5, 2-(3-Aminophenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C8H11NO, blongs to alcohols-buliding-blocks compound. Formula: C8H11NO
The compounds were treated with p-chlorobenzoic acid (586 mg, 3.76 mmol), triethylamine (578 mL, 4.18 mmol) and HBTU(1580 mg, 4.18 mmol)Dissolved in methylene chloride,After stirring for 15 min, add3-aminophenylethanol2a (286 mg,2.09 mmol), 25 C for 12 hours,After completion of the reaction, the reaction solution was concentrated under reduced pressure,Add distilled water and extract with ethyl acetate(50 mL x 2), saturated brine,The organic phases were combined, dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressureChromatography (petroleum ether: ethyl acetate = 3: 1) to give the intermediate 2b (282.5 mg, 0.099 mmol, white solidBody, yield 49.6%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,52273-77-5, 2-(3-Aminophenyl)ethanol, and friends who are interested can also refer to it.
Reference:
Patent; Hefei University of Technology; Liao Chenzhong; Zhang Xingxing; Xiao Xuan; Zhan Meimiao; Ma Jingwen; Zhu Mimi; Li Yinfeng; Guan Li; (32 pag.)CN107056630; (2017); A;,
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