Electric Literature of 149104-89-2, Adding some certain compound to certain chemical reactions, such as: 149104-89-2, name is (4-Bromo-3-methylphenyl)methanol,molecular formula is C8H9BrO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 149104-89-2.
9.10 g of (4-bromo-3-methylphenyl)methanol was dissolved in 91 ML of methylene chloride and cooled to 5°C, to which 19.7 ML of N-ethyldiisopropylamine and 6.9 ML of chloromethyl methyl ether were successively added dropwise at 5 to 10°C, and then this mixture was stirred for 2.5 hours at room temperature.. water was added to the reaction mixture and adjusted to PH 7 with 6M hydrochloric acid, and then the organic phase was separated therefrom.. After the resultant organic phase was washed with water and a saturated sodium chloride solution successively, the washed phase was dried over anhydrous sodium sulfate, and the solvent was distilled out under reduced pressure.. The resultant residue was purified by silica gel column chromatography [eluent; hexane:ethyl acetate=5:1] to yield 10.44 g of 1-bromo-4-[(methoxymethoxy)methyl]-2-methylbenzene as yellow oil. NMR(400MHz,CDCl3) delta value: 2.40(3H,s), 3.41(3H,s), 4.52(2H,s), 4.71(2H,s), 7.04(1H,dd,J=8.2,2.0Hz), 7.23(1H,d,J=1.6Hz), 7.50(1H,d,J=8.0Hz)
According to the analysis of related databases, 149104-89-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; TOYAMA CHEMICAL CO., LTD.; Hirono, Shuichi; Shiozawa, Shunichi; EP1445249; (2004); A1;,
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