Synthetic Route of 6329-73-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6329-73-3, name is 1-(Benzo[d][1,3]dioxol-5-yl)ethanol, molecular formula is C9H10O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: To a stirred solution of alcohol (1 equiv) in dry DCM (10 to 20 mL), thionyl chloride (1 .7 to 3 equiv) was added slowly at 0 C. The reaction mixture was warmed to rt and was refluxed for 1 h. The reaction mixture was concentrated under vacuum and the resulting residue was diluted with DCM (20 to 50 mL). The DCM layer was washed with water (5 to 10 mL), brine solution (5 to 10 mL), dried over anhydrous Na2SO4 and concentrated under vacuum to give chloro compound.
According to the analysis of related databases, 6329-73-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ASCENEURON SA; QUATTROPANI, Anna; KULKARNI, Santosh S.; GIRI, Awadut Gajendra; (243 pag.)WO2016/30443; (2016); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts