Application of 17849-38-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 17849-38-6 as follows.
4-methyl-benzenesulfonamide (171mg, 1mmol), catalyst A (8.3mg, 0.01mmol, 1.0mol%), cesium carbonate (33mg, 0.1mmol, 0.1equiv.), 2- chlorobenzyl alcohol (171mg, 1.2 mmol) and water (1ml) were successively added 25ml Schlenk reaction flask.After the reaction mixture was reacted at 120 15 hours, cooled to room temperature.After the reaction mixture was reacted at 120 15 hours, cooled to room temperature.A large amount of precipitated, water was removed by filtration, the filter cake was washed with water three times to give the title compound, yield: 92%
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,17849-38-6, its application will become more common.
Reference:
Patent; Nanjing University of Science & Technology; Li, Feng; Qu, panpan; Sun, chunlou; Ma, Juan; (17 pag.)CN104418678; (2016); B;,
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