Related Products of 22436-06-2 , The common heterocyclic compound, 22436-06-2, name is (S)-2-Methyl-3-phenylpropan-1-ol, molecular formula is C10H14O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Acetyl chloride (1.816 g, 23.14 mmol) was added slowly to a solution of (±)-4a (1.728 g, 11.50 mmol) and dry pyridine (2.757 g,34.85 mmol) in dry CH2Cl2 (30 mL) at 0 C. The reaction mixture was stirred overnight at room temperature. The reaction was quenched with water (30 mL) at 0 C. The mixture was extracted with Et2O (50 mL). The organic layer was washed with brine (30 mL), dried over anhydrous Na2SO4 and filtered. After removal ofthe solvent, the residue was purified by column chromatography on silica gel (hexane/EtOAc 5/1) to afford (±)-5a (2.079 g, 94%) as a colorless oil. 1H NMR data were identical to those reported in the literature [40].
The synthetic route of 22436-06-2 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Kato, Daiki; Kawasaki, Masashi; Morita, Yuko; Okada, Takuya; Tanaka, Yasuo; Toyooka, Naoki; Tetrahedron; (2020);,
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