Adding a certain compound to certain chemical reactions, such as: 552331-15-4, 1-(5-Bromo-2-fluorophenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 1-(5-Bromo-2-fluorophenyl)ethanol, blongs to alcohols-buliding-blocks compound. Recommanded Product: 1-(5-Bromo-2-fluorophenyl)ethanol
Step 2 [0202] To a solution of Compound 2 (14.01 g) in ethyl acetate (150 ml) was added 2-iodoxybenzoic acid (35.8 g), and the mixture was refluxed for 7 hours. The reaction solution was cooled in an ice bath and the precipitated solid was removed by filtration. The filtrate was evaporated under reduced pressure to afford Compound 3 (13.66 g) [0203] 1H-NMR (CDCl3) delta: 2.64 (d, J=5.0 Hz, 3H), 7.05 (dd, J=10.2, 8.7 Hz, 1H), 7.58-7.64 (m, 1H), 7.98 (dd, J=6.4, 2.5 Hz, 1H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,552331-15-4, 1-(5-Bromo-2-fluorophenyl)ethanol, and friends who are interested can also refer to it.
Reference:
Patent; SHIONOGI & CO., LTD.; Masui, Moriyasu; Tadano, Genta; US2013/210839; (2013); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts