The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 27871-49-4, name is (S)-Methyl 2-hydroxypropanoate. This compound has unique chemical properties. The synthetic route is as follows. Formula: C4H8O3
Under an Ar atmosphere, to a solution of methyl L-lactate (10.0 g, 96.1 mmol) in THF (100.0 mL) were added NEt3 (33.5 mL 240.2 mmol), DMAP (1.17 g, 9.6 mmol) and TBSCl (19.3 g, 128.1 mmol) at 0C, and the mixture was stirred for 24 h at r.t. The reaction mixture was diluted with Et2O, successively washed with 10% HCl aq. and sat. NaHCO3 aq., dried over MgSO4, filtered, and concentrated in vacuo. The resulting oil was purified by column chromatography on silica gel (hexane:AcOEt = 5:1) to afford the TBS ether (S-1) (20.9 g, 95.5 mmol, 99%) as a colorless oil.
With the rapid development of chemical substances, we look forward to future research findings about 27871-49-4.
Reference:
Article; Sugimoto, Kenji; Kobayashi, Yuta; Hori, Ayana; Kondo, Takashi; Toyooka, Naoki; Nemoto, Hideo; Matsuya, Yuji; Tetrahedron; vol. 67; 40; (2011); p. 7681 – 7685;,
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