Adding a certain compound to certain chemical reactions, such as: 2503-56-2, 7-Hydroxy-5-methyl-1,3,4-triazaindolizine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C6H6N4O, blongs to alcohols-buliding-blocks compound. Computed Properties of C6H6N4O
The formed 5-Methyl-[1,2,4] triazolo [1,5-a]Pyrimidin-7-ol (1.0 equiv) was added to 2.75 mL (3.0 equiv) of phosphorous oxychloride and heated under reflux for 90 min in a round bottom flask. Excess phosphorous oxychloride was removed under reduced pressure on a rotatory evaporator, and the residue was triturated with ice water. The product was extracted from the aqueous mixture with CH2Cl2, organic layer was dried over sodium sulphate, evaporated at reduced pressure, and purified by column chromatography using 60% EtOAc/hexane. 4.2.2.1. 7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine (7). White-yellow solid; Yield: 55%; mp: 150 C; ESI-MS: m/z 169.1[M+H]+; 1H NMR (300 MHz, CDCl3): delta 8.50 (s, 1H, Triazolopyrimidine-Hb), 7.15 (s, 1H, Triazolopyrimidine-Ha), 2.75 (s, 3H, Triazolopyrimidine-CH3).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,2503-56-2, 7-Hydroxy-5-methyl-1,3,4-triazaindolizine, and friends who are interested can also refer to it.
Reference:
Article; Jameel, Ehtesham; Meena, Poonam; Maqbool, Mudasir; Kumar, Jitendra; Ahmed, Waqar; Mumtazuddin, Syed; Tiwari, Manisha; Hoda, Nasimul; Jayaram; European Journal of Medicinal Chemistry; vol. 136; (2017); p. 36 – 51;,
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