Electric Literature of 100-37-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 100-37-8, name is 2-(Diethylamino)ethanol, molecular formula is C6H15NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
diethylaminoethyl methacrylate is synthesized by using diethylaminoethanol and methyl methacrylate as raw materials and lithium hydroxide as a catalyst. The process steps are as follows:(1) Synthesis: 300 g (3.0 mol) of methyl methacrylate, 117 g (1.0 mol) of diethylaminoethanol, 10 g of lithium hydroxide and 0.6 g of hydroquinone were added to a 1000 mL with stirring, a thermometer and a vacuum fractionation apparatus. The three-necked flask was heated to 75 C to 85 C, and the temperature at the top of the column was controlled to be 50 C to 55 C. The methanol was continuously separated under a negative pressure of about 600 mmHg, and the reaction was stopped until no methanol was separated (about 3.5 h). Methanol 33.0 g was separated, and gas chromatographic analysis showed that the methanol content was 89.3% and the methyl methacrylate content was 9.6%.(2) Purification: Cool to room temperature and wash twice with 300 mL × 2 of deionized water. The oil phase is gradually depressurized (40-100 mmHg), and unreacted methyl methacrylate and diethylaminoethanol are distilled off at 70 C to 100 C, and then distilled under reduced pressure at 5 to 10 mmHg and 90 C to 100 C. Diethylaminoethyl acrylate. The weight of the obtained mixture of methyl methacrylate and diethylaminoethanol was 195.8 g, and gas chromatographic analysis showed that the methyl methacrylate content was 95.9% and the diethylaminoethanol content was 3.6%. This mixture can be used directly for the synthesis of diethylaminoethyl methacrylate. The weight of the obtained product was 174.1 g (theoretical yield: 185.26 g), and the yield was 94.0%. The gas chromatographic analysis showed that the content of diethylaminoethyl methacrylate was 99.4%.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 100-37-8, 2-(Diethylamino)ethanol.
Reference:
Patent; Sinopec Corporation; Sinopec Corporation Victory Oil Field Fen Corporation Petroleum Engineering Technology Institute; Zhang Songting; Yang Shengli; Bai Xin; Rong Yan; Du Chunan; Chen Xiaochun; Cai Qingjun; Ma Tiantai; Sun Lizhu; Yue Jiwen; (10 pag.)CN108976136; (2018); A;,
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