Synthetic Route of 7589-27-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 7589-27-7, name is 2-(4-Fluorophenyl)ethanol. A new synthetic method of this compound is introduced below.
To a solution of 4-fluorophenethyl alcohol (1.40 g, 10 mmol, 1.25 mL, 1 eq), Et3N (3.04 g, 30 mmol, 4.16 mL, 3 eq) in DCM (20 mL) was added MsCl (1.49 g, 13 mmol, 1.01 mL, 1.30 eq) at 0 °C. The mixture was stirred at 0 °C for 30 min. Water (10 mL) was added to the mixture and the organic layer isolated. The water layer was further extracted with DCM (10 mL* 2). The combined organic layers were dried over anhydrous sodium sulfate and concentrated in vacuo to afford the target compound as a yellow oil (1.8 g, 83.5percent). NMR (400MHz, CD3OD) delta 7.33 – 7.25 (m, 2H), 7.07 – 7.00 (m, 2H), 4.40 (t, J=6.8 Hz, 2H), 3.02 (t, J=6.8 Hz, 2H), 2.95 (s, 3H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,7589-27-7, its application will become more common.
Reference:
Patent; CHRYSALIS, INC.; GWALTNEY, Stephen; (167 pag.)WO2017/143011; (2017); A1;,
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