With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.627-18-9, name is 3-Bromopropan-1-ol, molecular formula is C3H7BrO, molecular weight is 138.9911, as common compound, the synthetic route is as follows.Computed Properties of C3H7BrO
General procedure: Concentrated H2SO4 (1 mL) was added into the fuming HNO3 (0.84 mL) at 0 C and stirred for 10 min. Dichloromethane (DCM,10 mL) and 1-bromo-3-propanol (0.9 mL, 10 mmol) were put in dropwise. The reaction mixture was stirred at room temperaturefor another 3 h, then poured into 10 mL of H2O, and extracted with DCM (10 mL 3). The organic layer was combined, washed with saturated NaCl solution, dried over anhydrous Na2SO4, and concentrated concentrated in vacuo to give the crude product 3a. 3b was obtained according to similar procedures. No further purification was needed for the next step.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,627-18-9, 3-Bromopropan-1-ol, and friends who are interested can also refer to it.
Reference:
Article; Zhao, Nan; Tian, Kang-Tao; Cheng, Ke-Guang; Han, Tong; Hu, Xu; Li, Da-Hong; Li, Zhan-Lin; Hua, Hui-Ming; Bioorganic and Medicinal Chemistry; vol. 24; 13; (2016); p. 2971 – 2978;,
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