Electric Literature of 13330-96-6 , The common heterocyclic compound, 13330-96-6, name is 4-(Dimethylamino)butan-1-ol, molecular formula is C6H15NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Example 36; 2-Butoxy-8-hydroxy-9-{3-[(4-dimethylaminobutoxy)carbonylmethyl]benzyl}adenine; 2-Butoxy-8-hydroxy-9-(3-carboxymethylbenzyl)adenine (88mg, 0.24mmol)which was prepared in Reference example 76 was suspended in DMF (10ml). Thereto were added at 0C 4-dimethylaminobutanol (0.16 ml, 1.18mmol), 1-hydroxybenzotriazole (0.16g, 1.18mmol) and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (0.23g, 1.18 mmol) in this order and the mixture was stirred at room temperature for 6 hours. After removal of the solvent by an evaporator, an aqueous saturated sodium bicarbonate solution was added to this residue and the resulted precipitate was filtered, followed by washing with water to give the titled compound as a white solid (73mg, 0.16mmol). Yield: 65% 1H NMR(DMSO-d6)delta 9.97(1H, brs), 7.20(4H, m), 6.45(2H, brs), 4.82(2H, s), 4.14(2H, t, J = 6.6 Hz), 4.00(2H, t, J = 6.6 Hz), 3.62(2H, s), 2.11(2H, t, J = 7.0 Hz), 2.04(6H, s), 1.62(2H, m), 1.51 (2H, m), 1.36(4H, m), 0.90(3H, t, J = 7.4 Hz).
The synthetic route of 13330-96-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Dainippon Sumitomo Pharma Co., Ltd.; AstraZeneca AB; EP1728792; (2006); A1;,
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