Adding a certain compound to certain chemical reactions, such as: 101597-25-5, 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C17H16O3, blongs to alcohols-buliding-blocks compound. HPLC of Formula: C17H16O3
General procedure: A solution of the naphthol (1 mol equiv) and the appropriate 1,1-bis(4-methoxyphenyl)prop-2-yn-1-ol (1 mol equiv), in the presence of pyridinium p-toluenesulfonate (PPTS) (5 mole %) and trimethyl orthoformate (2 mol equiv) in 1,2-dichloroethane (150 mL),was heated under reflux for up to 4 h (the reaction time being determined by TLC examination of the reaction mixture). The cooled solvent was removed under vacuum to afford the crude product, which was either purified by flash column chromatography or by crystallisation. The following compounds were obtained in this manner: 4.8.1. 3-Benzoyl-6,6-bis(4-methoxyphenyl)-6H-benzo[h]furo[3,2-f]chromene 9. 3-Benzoyl-6,6-bis(4-methoxyphenyl)-6H-benzo[h]furo[3,2-f]chromene 9 from 7 and 8 as pale pink microcrystals after crystallisation from EtOAc and hexane, 52.4%, mp 188 – 190C; upsilonmax 2831, 1651, 1606, 1506, 1351, 1236, 1173, 1028, 1017, 876, 836, 726, 706, 683, 663, 646 cm-1; deltaH (CDCl3) 3.76 (6H, s, OMe), 6.13 (1H, d, J9.9 Hz, 5-H), 6.82 e6.85 (4H, m, AreH), 7.44 e7.47 (4H, m, AreH),7.51 e7.65 (6H, m, AreH, 4-H), 7.93 e7.95 (2H, m, Ar eH), 8.02 (1H, s,2-H), 8.19 (1H, d, J 7.8 Hz, Ar eH), 8.45 (1H, d, J 8.1 Hz, AreH); deltaC(CDCl3) 55.22, 82.22, 110.56, 113.38, 117.80, 119.99, 121.17, 122.83,123.08, 123.64, 124.09, 125.90, 127.09, 127.11, 128.28, 128.62, 129.67,132.92, 137.34, 139.29, 145.27, 147.04, 151.68, 158.84, 190.48 (Found M+H+, 539.1844; C36H26O5 requires M+H+, 539.1853).
The synthetic route of 101597-25-5 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Aiken, Stuart; Allsopp, Ben; Booth, Kathryn; Gabbutt, Christopher D.; Heron, B. Mark; Rice, Craig R.; Tetrahedron; vol. 70; 49; (2014); p. 9352 – 9358;,
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