Synthetic Route of 349-75-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.349-75-7, name is (3-(Trifluoromethyl)phenyl)methanol, molecular formula is C8H7F3O, molecular weight is 176.14, as common compound, the synthetic route is as follows.
Sequentially capturing meso-Co-N / C (800) (35mg, 0.25mol% Co), 3- trifluoromethyl-benzyl alcohol (176mg, 1mmol), a concentration of 28 mass% aqueous ammonia (280 L) was added to the reaction flask 10ml and tert-amyl alcohol was added 1ml of solvent placed in the reaction vessel, the oxygen charged to 1Mpa, placed in an oil bath of 130 and then detecting the extent of reaction by GC-MS.After completion of the reaction, the biphenyl internal standard was added, the product was analyzed 3-trifluoromethyl-benzonitrile quantitative yield by GC.The reaction 24h, 3- trifluoromethyl-benzonitrile in 83% yield, selectivity of 99%.
The chemical industry reduces the impact on the environment during synthesis 349-75-7, I believe this compound will play a more active role in future production and life.
Reference:
Patent; Dalian Institute of Chemical Physics; Gao Shuang; Shang Sensen; Wang Lianyue; Lv Ying; (7 pag.)CN106883143; (2017); A;,
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