Electric Literature of 20712-12-3, Adding some certain compound to certain chemical reactions, such as: 20712-12-3, name is (2-Amino-5-bromophenyl)methanol,molecular formula is C7H8BrNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 20712-12-3.
(l) To a mixture of lithium aluminum hydride (2.6 g, 69 mmol) in diethyl ether (54 ml) was added dropwise 5-bromoanthranillic acid methyl ester (6.3 g, 27 mmol) in diethyl ether (54 ml) at Ot). The mixture was stirred at O1C for 3 hours. Then water (2.6 ml), 15 wtpercent aqueous solution of sodium hydroxide (2.6 ml) and water (7.8 ml) was addedsequentially at O1C. The mixture was filtrated through a pad of Celite, and concentrated in vacuo. The residue was dissolved into tetrahydrofuran (160 ml), and triethylamine (15 g, 150 mmol) was added. The mixture was cooled to Ot, and trichloromethyl chloroformate (2.9 g, 15 mmol) was added. The mixture was stirred at room temperature for 4 hours. The mixture was partitioned between water and ethyl acetate. The organic layer was washed with brine, dried over sodium sulfate, and concentrated in vacuo to afford crude product. This crude product was washed with diethyl ether to afford6-bromo-l,4-dihydro-2H”3,l-benzoxazin-2-one as a colorless solid (4.7g, 21 mmol, 77percent).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 20712-12-3, (2-Amino-5-bromophenyl)methanol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MITSUBISHI TANABE PHARMA CORPORATION; SANOFI-AVENTIS; NAKAYAMA, Kazuki; SAKAI, Daiki; WATANABE, Kazutoshi; KOHARA, Toshiyuki; ARITOMO, Keiichi; WO2011/19090; (2011); A1;,
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