Related Products of 59101-28-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 59101-28-9, name is 16-Bromohexadecan-1-ol, molecular formula is C16H33BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
4.3 Diethyl2-acetamido-2-(i 6-hydroxyhexadecyl)malonate10221] The bromide 15(0.967 g, 2.70 mmol), diethyl 2-ac- etamidomalonate 1 (0.640 g, 2.8 mmol, 1.0 eq.) (obtained as in example 1.1 above) and caesium carbonate (1.680 g, 5.17 mmol, 1.9 eq.) were suspended in acetonitrile (20 mE) and refluxed for 5 h. The mixture was adsorbed at silica gel (1-2 g) and purified by colunm chromatography (silica gel, 1 6.5×4 cm, cyclohexane/ethyl acetate, 4:i)to give a yellowish solid. Yield: 0.912 g (74%).10222] M.p.: 48 C.10223] ?R-NMR (300 MHz, CDC13) oe [ppm]: 1.23-1.63(m, 34R, 5-CR2 to 18-CR2, 23-CR3, 25-CR3), 2.04 (m, 4R,21-CR3, 19-OR), 2.30 (m, 2R, 4-CR2), 3.63 (t, 3J,y=6.6 Rz,2R, 19-CR2), 4.20 (m, 4R, 22-CR2, 24-CR2), 6.84 (s, 1R,2-NR).10224] ?3C-NMR (75 MRz, CDC13) oe [ppm]: 14.0 (q, C-23,C-25), 23.1 (q, C-21), 23.6 (t, C-5), 25.8 (t, C-17), 28.4,29.3,29.7 (t, C-6 to C-16), 32.1 (t, C-18), 32.8 (t, C-4), 62.5 (t,C-22, C-24), 63.0 (t, C-19), 66.6 (s, C-2), 168.3 (s, C-i, C-3),169.0 (s, C-20).10225] Exact mass (ESI): C25R47NO5+Na: calcd. 480.3296, found 480.3300; (C25R47NO5)2+Na: calcd. 937.6699,found 937.6713.
According to the analysis of related databases, 59101-28-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER; Haufe, Guenter; Levkau, Bodo; Schaefers, Michael; Schilson, Stefani Silke; Keul, Petra; US2014/170067; (2014); A1;,
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