Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 16369-21-4, name is 2-(Propylamino)ethanol. A new synthetic method of this compound is introduced below., Application In Synthesis of 2-(Propylamino)ethanol
Preparation 17 4-propylmorpholine-2-one Methyl 2-bromoacetate (50 mL, 0.54 mol, 1 eq) was added slowly to N-propylaminoethanol (62.4 ml, 0.54 mol, 1 eq) and Et3N (75 ml, 0.54 mol, 1 eq) in toluene at 0 C. and allowed to stir at room temperature overnight. Water (1 L) was added, and the mixture extracted with EtOAc (2*500 mL). Brine (500 mL) was added to the aqueous layer, which was re-extracted with EtOAc (2*500 mL). Organic layers were combined, dried (MgSO4), filtered and solvent removed in vacuo to give 62.7 g (81%) of title compound as a clear oil. TLC EtOAc Rf=0.5 M/S (APCI+) 144 (MH+) 1H NMR (400 Mhz, CD3OD) deltaH 0.9 (t, 3H), 1.4-1.6 (m, 2H), 2.3-2.4 (m, 2H), 2.6-2.7 (m, 2H), 3.3 (s, 2H), 4.4 (m, 2H)
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Reference:
Patent; Pfizer Inc; US2005/267096; (2005); A1;,
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