Electric Literature of 3973-18-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3973-18-0, name is Propynol ethoxylate, molecular formula is C5H8O2, molecular weight is 100.1158, as common compound, the synthetic route is as follows.
To a degassed solution of 4-bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-l,3-dione (10.0 g, 29.66 mmol) in dry N,N-dimethylformamide (160 mL) were added [l,r-Bis(diphenylphosphino)ferrocene]dichloropalladium (II) dichloromethane adduct (3.1 g, 4.44 mmol), copper(I) iodide (1.4 g, 7.36 mmol), N-ethyl-N-isopropylpropan-2-amine (100 mL) and 2-(prop-2-yn-l-yloxy)ethan-l-ol (4.4 g, 44.34 mmol). The resulting mixture was stirred at 80 C for 16 h under nitrogen. The reaction mixture was diluted with water and extracted with ethyl acetate. The combined organic layer was washed with water and brine, dried over anhydrous sodium sulfate, filtered and concentrated under vacuum. The residue was purified by flash column chromatography with 0-100% ethyl acetate in petroleum ether to afford 2-(2,6-dioxopiperi din-3 -yl)-4-(3 -(2-hydroxyethoxy)prop- 1 -yn- 1 -yl)isoindoline- 1,3- dione (3.0 g, 28%) as a gray solid. MS (ESI) calc?d for (C18H16N2O6) [M+H]+, 357.1; found, 357.0.
Statistics shows that 3973-18-0 is playing an increasingly important role. we look forward to future research findings about Propynol ethoxylate.
Reference:
Patent; NURIX THERAPEUTICS, INC.; ROBBINS, Daniel, W.; SANDS, Arthur, T.; MCINTOSH, Joel; MIHALIC, Jeffrey; WU, Jeffrey; KATO, Daisuke; WEISS, Dahlia; PENG, Ge; (415 pag.)WO2020/81450; (2020); A1;,
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