Adding a certain compound to certain chemical reactions, such as: 5299-60-5, Ethyl 6-hydroxyhexanoate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: Ethyl 6-hydroxyhexanoate, blongs to alcohols-buliding-blocks compound. Recommanded Product: Ethyl 6-hydroxyhexanoate
Example 1 : Preparation of tetranor-PGDMPreparation of Ester (2A) from 6-hydroxyhexanoate (1A EtO.OTBDMSO2A(2, wherein R is ethylR2 is methyl, andR3 is ieri-butyl)- 50.0 g (312.1 mmol) of ethyl 6-hydroxyhexanoate (1A)- 61.15 g (405.72 mmol) of TBDMSC1;- 42.5 g (624.2) of imidazole;- 500 ml of DMF.[0048] A solution of ethyl 6-hydroxyhexanoate (1 A) in dry DMF was cooled with an ice bath and treated with TBDMSC1 and imidazole portion wise for 10 minutes. The cooling bath was removed and the reaction mixture was stin-ed overnight (controlled by TLC, hexane – ethyl acetate 90: 10). The next day the reaction mixture was treated with ice (200 g), stirred for 5 minutes, and extracted with H-EA (10: 1 , 800 ml, 2×200 ml). The combined organic phases were washed with water-brine (1 : 1 , 2 x 100 ml), brine (100 ml), dried over Na2SC>4, and evaporated. The residue was purified by flash chromatography: Silica gel (300 g), hexane (H) – ethyl acetate (EA) 100: 1 – 70: 1. The mass of the collected product (Ester (2 A)) was 81.5 g (95%), TLC Rf = 0.8 (solvent system: hexane – ethyl acetate 90: 10).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,5299-60-5, Ethyl 6-hydroxyhexanoate, and friends who are interested can also refer to it.
Reference:
Patent; CAYMAN CHEMICAL COMPANY, INCORPORATED; ENDRES, Gregory, W.; KORNILOV, Andriy, M.; UZIEBLO, Adam; WO2011/159740; (2011); A2;,
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