As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 23147-58-2, name is Glycerol aldehyde dimer, molecular formula is C4H8O4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Formula: C4H8O4
To a solution of 4 (0.038 g, 0.094 mmol) in MeOH (5 mL) were added AcOH (0.108mL, 1.88 mmol, 20.0 equiv), NaBH3CN (0.018 g, 0.282 mmol, 3.0 equiv) and glycolaldehyde dimer (0.017 g, 0.141 mmol, 1.5 equiv). The reaction was warmed to 60 C and stirred for 2 hours, after which TLC analysis (CH2Cl2/MeOH/NH4OH84:15:1) showed full conversion of the starting material. The reaction mixture was concentrated in vacuo, the residue dissolved in MeOH, absorbed onto celite and purified by flash column chromatography (CH2Cl2/MeOH/NH4OH 99:0:1 to 79:20:1) to afford 3a (39 mg, 0.087 mmol, 93% yield) as a white solid.
With the rapid development of chemical substances, we look forward to future research findings about 23147-58-2.
Reference:
Article; Bouton, Jakob; Van Hecke, Kristof; Rasooly, Reuven; Van Calenbergh, Serge; Beilstein Journal of Organic Chemistry; vol. 14; (2018); p. 2822 – 2828;,
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