Reference of 5299-60-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5299-60-5, name is Ethyl 6-hydroxyhexanoate, molecular formula is C8H16O3, molecular weight is 160.21, as common compound, the synthetic route is as follows.
The PCC (16.20g, 75 . 50mmol) dissolved in dichloromethane (140 ml) in, lowering the temperature to 0 C, dropping 6 – hydroxy hexanoic acid ester (10.30g, 64 . 30mmol) of dichloromethane (20 ml) solution. Heating the reaction to room temperature, stirring the reaction 2 hours, adding ethyl acetate (100 ml), filtered, the filtrate is concentrated. The residue by silica gel column chromatography (petroleum ether/ethyl acetate (v/v)=10/1) to obtain the title compound as white solid (9.28g, 45.0%).
Statistics shows that 5299-60-5 is playing an increasingly important role. we look forward to future research findings about Ethyl 6-hydroxyhexanoate.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jin Chuanfei; Gao Jinheng; Zhang Yingjun; (37 pag.)CN106279153; (2017); A;,
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