Reference of 109-83-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 109-83-1 as follows.
To a solution of 2,6-dibromobenzaldehyde (12 g, 45.5 mmol) in MeOH (120 mL)was added NaBH4 (1.89 g, 50.0 mmol) portionwise.The mixture was stirred at roomtemperature for 1 h, quenched slowly with sat. NH4C1, and extracted with EtOAc. The combined organics were washed with brine, dried over Na2SO4 and concentrated to give the title compound. ?H NMR (400 MHz, CDC13) oe 7.55 (d, J= 7.9 Hz, 1H), 7.02 (t, J= 7.9 Hz, 1H), 5.00 (d, J 6.6 Hz, 2H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,109-83-1, its application will become more common.
Reference:
Patent; MERCK SHARP & DOHME CORP.; ZHANG, Hongjun; BARR, Kenneth, Jay; LAPOINTE, Blair, T.; GUNAYDIN, Hakan; LIU, Kun; TROTTER, B., Wesley; (67 pag.)WO2017/75185; (2017); A1;,
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