With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.10160-24-4, name is 7-Bromo-1-heptanol, molecular formula is C7H15BrO, molecular weight is 195.0974, as common compound, the synthetic route is as follows.Recommanded Product: 7-Bromo-1-heptanol
Add 8.4 g (0.1 mol) of methyl propiolate to a 100 mL single-mouth bottle. 30 mL of dry tetrahydrofuran and 4.5 g of gram (0.115 mol) sodium amide, and the mixture was stirred at room temperature for about 15 minutes. then 21.34 g (0.11 mol) of 7-bromoheptanol was added dropwise. after 0.5 h of dropwise addition, the reaction was continued for 3.0 h. After the completion of the reaction, the tetrahydrofuran was removed in vacuo, and the residue was dissolved in dichloromethane, washed with water, and then evaporated. the filtrate was evaporated to give a pale yellow oily liquid product II compound 19.2 g, yield 97%
At the same time, in my other blogs, there are other synthetic methods of this type of compound,10160-24-4, 7-Bromo-1-heptanol, and friends who are interested can also refer to it.
Reference:
Patent; Jiaxing College; Li Meng; Zong Qianshou; Liu Xuejun; Wang Lu; Dai Jingjing; Zhang Yajing; Zheng Yannan; Zhou Hongwei; Bao Lin; (7 pag.)CN109942397; (2019); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts