Related Products of 33420-52-9, Adding some certain compound to certain chemical reactions, such as: 33420-52-9, name is 2,2-Difluoropropan-1-ol,molecular formula is C3H6F2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 33420-52-9.
To a solution of 2,2-difluoropropan-1-ol (5.00 g, 52.0 mmol) and triethylamine (9.40mL, 67.6 mmol) in DCM (75 mL) was added trifluoromethanesulfonic anhydride (10.5 mL, 62.4mmol) dropwise at -20 C, and then allowed to move to 0 C, stirred overnight. The mixture wasdiluted with DCM (75 mL), then poured into ice water (100 mL). The separated organic layerwas washed with 20% Na2C03 aqueous solution (50 mL) and brine (50 mL) successively, anddried over Na2S04, filtered and concentrated in vacuo to afford the target compound as black oil(11.41 g, yield 96.1%).1HNMR (400 MHz, DMSO-d6) 8 (ppm): 5.08 (t, J= 13.5 Hz, 2H), 1.72 (t, J= 19.3 Hz, 3H);19F NMR (376 MHz, DMSO-d6) 8 (ppm): -74.6, -99.7.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 33420-52-9, 2,2-Difluoropropan-1-ol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; CALITOR SCIENCES, LLC; DAI, Weilong; XI, Ning; LI, Minxiong; ZHANG, Tao; LI, Xiaobo; HU, Haiyang; CHEN, Wuhong; WANG, Tingjin; LIU, Jun; (188 pag.)WO2017/48675; (2017); A1;,
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