Adding a certain compound to certain chemical reactions, such as: 33420-52-9, 2,2-Difluoropropan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 33420-52-9, blongs to alcohols-buliding-blocks compound. SDS of cas: 33420-52-9
To a solution of 2,2-difluoropropan-1-ol (I-10A-7b; 1.76 g, 18.3 mmol), dimethylaminopropylamine (DMAP: 157 mg, 1.3 mmol), and triethylamine (2.20 g, 3.1 ml, 22 mmol) in CH2Cl2 (15 ml) at 0 C. was added triflic anhydride (Tf2O; 6.2 g, 3.7 ml, 22 mmol). The reaction mixture initially turned a pink color, then a yellow color following the complete addition of Tf2O. The reaction mixture was stirred at 0 C. for 2 hours and diluted with CH2Cl2. The organic solution was washed with water, 1 M aqueous citric acid, and saturated aqueous NaHCO3, dried, and concentrated under reduced pressure (225 mm/Hg; bath temperature -30 C.) to give the desired product, trifluoromethanesulfonic acid 2,2-difluoropropyl ester (I-10A-7c), as a pink oil (3 g, 72%): 1H NMR (400 MHz, CDCl3) delta 4.49 (t, J=10.8 Hz, 2H), 1.74 (t, 3H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,33420-52-9, its application will become more common.
Reference:
Patent; Pfizer Inc.; US2004/214837; (2004); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts