Reference of 66582-32-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 66582-32-9, name is 3-(Benzyloxy)-2,2-dimethylpropan-1-ol, molecular formula is C12H18O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: To a solution of oxalyl chloride (40 mmol,2 eq), in dichloromethane (20 mL) at -78C, was added DMSO (80 mmol, 4 eq) in dichloromethane(20 mL) dropwise. After stirring during 30 min, a solution of monobenzylated diol (20 mmol, 1 eq)in dichloromethane (20 mL) was added dropwise. The mixture was stirred 2 h, and triethylamine (6eq) in CH2Cl2 (15 mL) was added dropwise. The mixture was allowed to reach room temperature,and quenched with 50 mL of water. The organic layers were washed with a solution of saturated NaCl, then dried over anhydrous MgSO4, filtered and concentrated in vacuo. The yellow oil was purified by flash chromatography.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 66582-32-9, 3-(Benzyloxy)-2,2-dimethylpropan-1-ol.
Reference:
Article; Chalopin, Thibaut; Jebali, Khaoula; Gaulon-Nourry, Catherine; Denes, Fabrice; Lebreton, Jacques; Mathe-Allainmat, Monique; Tetrahedron; vol. 72; 2; (2016); p. 318 – 327;,
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