Application of 3319-15-1 ,Some common heterocyclic compound, 3319-15-1, molecular formula is C9H12O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
In assembling the magnetic force of the solder 25 ml glass tube by adding 1 mmol of 1 – (methoxyphenyl) ethanol (formula (1 – 5)), 0.1 mmol of I2, 0.1 Mmol of Fe (NO3)3· 9 H2O, 2 ml of DMSO, oxygen is used for replacement in the glass tube after the air sealing glass tube, will then be sealed glass tube is put into the pre-heating to 130 C the pot of the oil bath, and opening of the magnetic stirrer, reaction 12 h after, is taken out of the sealed glass tube, to be its cooling to room temperature, the reaction solution is added in the quenching reaction, then the concentration of 0.1 mol/L of sodium hydroxide solution to adjust the pH to 11 the left and right, for washing three times with ethyl acetate, the aqueous phase is in a concentration of 0.1 mol/L hydrochloric acid solution to pH value to 2 the left and right, then the extraction three times with ethyl ether, the merging of the three times of the ether extract, reducing pressure and ethyl ether, then column chromatography, using ethyl acetate/petroleum ether volume ratio 1:25 of the mixed solution is the eluant, collecting the eluant containing the compound, evaporate the solvent to get the product to the anisic acid, separating the yield is 73%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3319-15-1, 1-(4-Methoxyphenyl)ethanol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Zhejiang University of Technology; Li Meichao; Wang Yuru; Xu Liang; Shen Zhenlu; (9 pag.)CN108821931; (2018); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts