Reference of 162744-59-4, Adding some certain compound to certain chemical reactions, such as: 162744-59-4, name is (4-Bromo-2,6-difluorophenyl)methanol,molecular formula is C7H5BrF2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 162744-59-4.
((4-bromo-2,6-difluorobenzyl)oxy)(tert-butyl)dimethylsilane A mixture of (4-bromo-2,6-difluorophenyl)methanol (7.5 g, 33.5 mmol), TBDMSCl (10.8 g, 67.0 mmol) and imidazole (3.0 g, 40.2 mmol) in DMF (70 mL) was stirred at 20C under N2 atmosphere for 2 hours, quenched with water (350 mL) and extracted with EtOAc (200 mL*3). The combined organic layers were dried over anhydrous Na2SO4, filtered and concentrated. The residue was purified by silica gel column chromatography to give Compound 17A (colorless oil, 10.2 g, 90% yield). LCMS (ESI) m/z: 338 (M+H+).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 162744-59-4, (4-Bromo-2,6-difluorophenyl)methanol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Medshine Discovery Inc.; LONG, Chaofeng; CHEN, Shuhui; CHEN, Xiaoxin; LUO, Yunfu; LIU, Zhuowei; PAN, Jianfeng; (56 pag.)EP3287453; (2018); A1;,
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