Related Products of 112-27-6 , The common heterocyclic compound, 112-27-6, name is 2,2′-(Ethane-1,2-diylbis(oxy))diethanol, molecular formula is C6H14O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Triethylenc glycol (17.5 mL, 19.7 g, 131.13 mmol. 5 eq) was dissolved in DCM (150 mL·} and trimethyiamine (5.48 mL, 3.98 g, 1.5 eq) and cooled to 0. TsCI (5.00 g, 26.23 mmol 1 eq) was then added and die reaction mixture stirred at room temperature tor 18 hours. The reaction was diluted into DCM and washed with water (3x) and brine (lx). The organic layer was dried over sodium sulfate and concentrated in. vacuo. The crude product was purified on silica (0-5% MeOH in DCM) to give compound 64 (6,89 g, 22,6 mmol) in 85% yield. lH NMR (400 MHz, Chloroform-t/) 6 7.80 (d, J – 8.3 Hz, 2H), 7.38 ~ 7.30 (m, 2H)S 4.23 4.14 (m, 2H), 3.71 (id, J = 5.3, 4.3 Hz, 4H), 3.66 – 3.55 (m, 6H), 2.45 (s, 3H). C NMR (101 MHz, cdcl3) 144.98, 133.09, 129,95, 128.09, 72.58, 70.91 , 70.44, 69.28, 68.84, 1.88, 2 /76.
The synthetic route of 112-27-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; YALE UNIVERSITY; SPIEGEL, David; CAIANIELLO, David; (247 pag.)WO2019/199621; (2019); A1;,
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