Related Products of 13674-16-3 , The common heterocyclic compound, 13674-16-3, name is Methyl 2-hydroxy-3-phenylpropanoate, molecular formula is C10H12O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
The compound 5-hydroxy-6-nitro-1H-indazole-1-carboxylic acid tert-butyl ester (900 mg, 3.22 mmol), methyl 2-hydroxy-3-phenylpropionate (870 mg, 4.83 mmol) and triphenylphosphine (1.69g, 6.44mmol) was dissolved in dry THF (80mL) was added DIAD (1.3g, 6.44mmol) at 0 C, Stirrer at room temperature until the starting material is completely reacted.The solvent was spin dried, ethyl acetate (200mL * 3). The combined organic phases were dried, filtered, concentrated to give pale yellow solid product 5-((1-methoxy-1-carbonyl-3-phenylpropan-2-yl)oxo)-6-nitro-1H-indazole-1-carboxylic acid tert-butyl ester (1.4 g, yield 98%)
The synthetic route of 13674-16-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shanghai Hansen Bio-pharmaceutical Technology Co., Ltd.; Jiangsu Haosen Pharmaceutical Group Co., Ltd.; Liu Shiqiang; Zhou Yuanfeng; Bao Meng; Yuan Yida; Liu Lei; Bao Rudi; (57 pag.)CN109761986; (2019); A;,
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